Cell Reports MedicineApril 20, 2021

Co-dominant neutralizing epitopes make anti-measles immunity resistant to viral evolution

Allison J Greaney, Frances C Welsh, Jesse D Bloom
doi:10.1016/j.xcrm.2021.100257

Abstract

Munoz-Alia and colleagues demonstrate that neutralizing antibody immunity to measles resists viral evolutionary escape because it targets numerous distinct viral epitopes. Their work contributes to our understanding of what determines whether a virus can evolve to evade immunity.